O304

O304 – Our lead AMPK activator

First-in-class AMPK activator – Unique mechanism of action. Mimics the multiple beneficial health effects of exercise and caloric restriction. Additional unique AMPK activators are in development.

AMPK is activated by the low energy state elicited by exercise & caloric restriction. By restoring energy charge, AMPK activation is beneficial for mitigating the large number of morbidities imposed by chronic metabolic perturbations coupled to a modern life-style and/or aging. Thus, pharmacological activation of AMPK is a promising approach to treat multiple diseases associated with a sedentary lifestyle and aging. Preclinical and clinical results with our lead first-in-class AMPK activator O304 support this concept.

Indications for Betagenon´s AMPK Activators:

Type 2 Diabetes
Diabetic Kidney Disease
Heart Failure
Obesity
NAFLD/NASH

Clinical development of lead AMPK activator O304:
Clinical trials